Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery

biomarker used for detection of pancreatic cancer. Recent … the discovery of candidate biomarkers for pancreatic cancer. CURRENT MS-BASED METHODS FOR …

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Review, Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery*, Ru Chen, Sheng Pan, Teresa A. Brentnall, and Ruedi Aebersold, Pancreatic cancer is a uniformly lethal disease that is, difficult to diagnose at early stage and even more difficult, to cure. In recent years, there has been a substantial, interest in applying proteomics technologies to identify, protein biomarkers for early detection of cancer. Quanti-, tative proteomic profiling of body fluids, tissues, or other, biological samples to identify differentially expressed pro-, teins represents a very promising approach for improving, the outcome of this disease. Proteins associated with, pancreatic cancer identified through proteomic profiling, technologies could be useful as biomarkers for the early, diagnosis, therapeutic targets, and disease response, markers. In this article, we discuss recent progress and, challenges for applying quantitative proteomics technol-, ogies for biomarker discovery in pancreatic cancer. Molecular & Cellular Proteomics 4:523-533, 2005. Molecular & Cellular Proteomics 4.4, This paper is available on line at http://www.mcponline.org, Proteomic Profiling of Pancreatic Cancer, Flow chart for biomarker discovery and development, using proteomic profiling. Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer, Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer, Protein categories identified in pancreatic cancer. Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer, Distribution of protein abun-, dance ratios in pancreatic cancer. Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer, Comparison of proteins identified in ICAT analysis of, pancreatic juice from cancer sample, pancreatitis sample, and, normal sample. Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer, Molecular & Cellular Proteomics 4.4, Proteomic Profiling of Pancreatic Cancer

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