Epothilones in patients with brain metastases from breast cancer

Breast Cancer Brain Metastases Workshop. Arlington, VA … Secondary. – Toxicity. – CNS response rate* and duration of response …

More PDF Content

Phase II Multicenter Study of Dose-intense (7days on/7days off) Temozolomide in Patients with Newly Diagnosed Pure and Mixed Anaplastic Oligodendroglioma

  • Take home points
    • Epothilones have potential advantages over taxanes particularly for brain metastases
    • At least 2 epothilones, patupilone and sagopilone, cross BBB
    • Clinical trial needs
      • Pre-irradiation studies
      • Combinations with existing agents
      • Neurocognitive/QOL endpoints
      • Imaging/biomarker correlates
  • Blood-brain barrier
    • Selection of drugs
    •  
      • lipid soluble
    • BCNU, CCNU
    • small molecules
    •  
      • cisplatin
      • hydroxyurea
      • procarbazine
      • temozolomide
    • Other issues
    •  
      • Efflux pumps
      • Protein binding
      • Tumor interstitial pressure
Download Epothilones in patients with brain metastases from breast cancer pdf from ctep.cancer.gov, 24 pages, 835.43KB.